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Understanding Your Medications After Joint Replacement Surgery

A Comprehensive Guide for Joint Replacement Patients

Orthopedics

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Last updated: Mar 24, 2025

Pain Management Medications

Prescription Pain Medications

Opioids (first 1-2 weeks)
- Oxycodone or Hydrocodone
- Take only as prescribed
- Discontinue when pain becomes manageable

Over-the-Counter Pain Relief

NSAIDs
- Ibuprofen (Advil®, Motrin®)
- Naproxen (Aleve®)
Acetaminophen (Tylenol®)

Blood Clot Prevention

Anticoagulants

Injectable medications
- Enoxaparin (Lovenox®)
- Duration: 2-4 weeks
Oral medications
- Rivaroxaban (Xarelto®)
- Apixaban (Eliquis®)

Infection Prevention

Antibiotics

Prescribed for first 24 hours post-surgery
Additional doses before dental procedures

Important Medication Guidelines

Timing
- Follow prescribed schedule strictly
- Use medication reminder apps/alarms
Side Effects
- Monitor for bleeding
- Watch for unusual bruising
- Report severe nausea or constipation
Storage
- Keep medications at room temperature
- Store away from direct sunlight
- Keep out of reach of children

When to Contact Your Doctor

Severe side effects
Unusual bleeding
Medication interactions
Questions about dosing

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