Understanding Nephrotic Syndrome in Children

A Comprehensive Guide for Parents and Caregivers

Pediatrics

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Last updated: Mar 24, 2025

What is Nephrotic Syndrome?

Nephrotic syndrome is a kidney condition that causes the body to excrete too much protein in the urine. It results in swelling (edema), particularly around the eyes, feet, and belly.

Key Symptoms

  • Swelling around eyes (periorbital edema), especially in the morning
  • Swollen feet and ankles
  • Puffy face
  • Swollen belly (ascites)
  • Foamy urine
  • Decreased urination
  • Fatigue and irritability

Common Causes

  • Minimal Change Disease (MCD): Most common cause in children
  • Focal Segmental Glomerulosclerosis (FSGS)
  • Genetic factors
  • Infections

Diagnosis

Tests typically include:

  1. Urine tests to measure protein levels
  2. Blood tests to check protein and cholesterol levels
  3. Possibly a kidney biopsy in certain cases

Treatment Options

First-line Treatment

  • Corticosteroids (usually prednisone)
  • Careful monitoring of fluid intake
  • Salt restriction

Additional Treatments

  • Diuretics to reduce swelling
  • ACE inhibitors or ARBs
  • Immunosuppressive medications in some cases

Managing at Home

  • Monitor weight daily
  • Track urine output
  • Follow a low-salt diet
  • Regular medication compliance
  • Keep a symptom diary

When to Seek Medical Care

  • Severe swelling
  • Difficulty breathing
  • Fever
  • Severe stomach pain
  • Signs of infection

Long-term Outlook

  • Most children respond well to treatment
  • Relapses are common but manageable
  • Many children outgrow the condition
  • Regular medical follow-up is essential

Prevention of Complications

  1. Regular monitoring
  2. Proper nutrition
  3. Maintaining medication schedule
  4. Avoiding infection triggers
  5. Regular exercise as appropriate

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