Understanding Lupus

A Comprehensive Guide to Systemic Lupus Erythematosus (SLE)

Internal Medicine

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Last updated: Mar 24, 2025

What is Lupus?

Lupus, or Systemic Lupus Erythematosus (SLE), is a chronic autoimmune disease where the body's immune system attacks its own tissues and organs. This can cause inflammation and damage throughout the body.

Key Symptoms

  • Fatigue
  • Joint pain and swelling
  • Butterfly-shaped rash across the cheeks and nose
  • Skin lesions that worsen with sun exposure
  • Fever
  • Chest pain
  • Shortness of breath
  • Dry eyes
  • Headaches

Who Gets Lupus?

Lupus primarily affects:

  • Women of childbearing age (15-44)
  • People of African, Asian, or Hispanic descent
  • Those with a family history of autoimmune diseases

Diagnosis

Diagnosis typically involves:

  1. Physical examination
  2. Blood tests (ANA, anti-dsDNA)
  3. Urine tests
  4. Tissue biopsies (when needed)

Treatment Options

Medications

  • Antimalarial drugs (hydroxychloroquine)
  • Corticosteroids
  • Immunosuppressants
  • NSAIDs for pain and inflammation

Lifestyle Changes

  • Sun protection
  • Regular exercise
  • Stress management
  • Healthy diet
  • Adequate rest

Living with Lupus

Managing Flares

  • Identify triggers
  • Monitor symptoms
  • Follow treatment plan
  • Regular medical check-ups

Complications

  • Kidney problems
  • Heart disease
  • Blood disorders
  • Increased infection risk

When to Seek Help

Contact your healthcare provider if you experience:

  • New or worsening symptoms
  • Severe pain
  • Unusual fatigue
  • Unexplained fever

Support and Resources

  • Join support groups
  • Connect with lupus organizations
  • Regular communication with healthcare team
  • Family education and involvement

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