Understanding Gallbladder Cancer

A Comprehensive Guide to Diagnosis, Treatment, and Management

Gastroenterology

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Last updated: Mar 24, 2025

What is Gallbladder Cancer?

Gallbladder cancer is a rare malignancy that begins in the cells of the gallbladder, a small pear-shaped organ located beneath the liver that stores bile.

Risk Factors

  • Age (over 65)
  • Female gender
  • Gallstones and chronic inflammation
  • Family history
  • Obesity
  • Porcelain gallbladder

Signs and Symptoms

Early Symptoms

  • Abdominal pain, especially in upper right portion
  • Nausea and vomiting
  • Loss of appetite

Later Symptoms

  • Jaundice (yellowing of skin and eyes)
  • Unexplained weight loss
  • Fever
  • Dark urine and light-colored stools

Diagnosis

Initial Assessment

  • Physical examination
  • Blood tests
  • Imaging studies (ultrasound, CT, MRI)

Confirmatory Tests

  • Biopsy
  • Staging investigations
  • Tumor marker tests

Treatment Options

Surgery

  • Simple cholecystectomy
  • Radical cholecystectomy
  • Palliative surgery

Other Treatments

  • Chemotherapy
  • Radiation therapy
  • Targeted therapy

Prognosis and Outlook

Prognosis depends on:

  • Cancer stage at diagnosis
  • Tumor size and spread
  • Patient's overall health
  • Response to treatment

Living with Gallbladder Cancer

Lifestyle Modifications

  • Balanced diet
  • Regular exercise as tolerated
  • Stress management
  • Regular medical follow-up

Support Resources

  • Support groups
  • Counseling services
  • Patient advocacy organizations
  • Financial assistance programs

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