Understanding Epidermolysis Bullosa (EB)

What is Epidermolysis Bullosa?

Epidermolysis bullosa (EB) is a group of rare genetic conditions that cause the skin to be very fragile and blister easily. The condition affects the skin and mucous membranes, making them extremely vulnerable to injury and friction.

Types of EB

• EB Simplex: Most common and generally milder form
• Dystrophic EB: Affects deeper skin layers
• Junctional EB: Severe form affecting the middle skin layer
• Kindler Syndrome: Mixed type with unique features

Common Symptoms

• Skin blistering with minor trauma
• Fragile skin that tears easily
• Thickened skin on palms and soles
• Nail changes or loss
• Internal blistering (mouth, esophagus)
• Dental problems

Diagnosis and Testing

1. Clinical examination
2. Skin biopsy
3. Genetic testing
4. Family history evaluation

Treatment and Management

Wound Care

• Gentle cleaning of blisters
• Specialized dressings
• Infection prevention

Pain Management

• Prescribed medications
• Topical treatments
• Lifestyle modifications

Supportive Care

• Nutritional support
• Physical therapy
• Occupational therapy
• Psychological support

Living with EB

Daily Precautions

• Avoid friction and trauma to skin
• Use soft clothing
• Maintain optimal temperature
• Regular medical check-ups

Support Resources

• Patient support groups
• Genetic counseling
• Specialized EB centers
• Family education programs

Research and Future Treatments

• Gene therapy developments
• Protein replacement studies
• Cell-based therapies
• Clinical trials