Understanding Diabetes Insipidus Medications: A Patient's Guide

Introduction

Diabetes insipidus (DI) is a rare condition affecting water balance in the body. This guide explains the medications used to treat different types of DI.

Types of Medications

1. Desmopressin (DDAVP)

• Primary medication for Central DI
• Available forms:
  • Nasal spray
  • Oral tablets
  • Sublingual melts
• Typical dosing: 1-3 times daily

2. Thiazide Diuretics

• Used for: Nephrogenic DI
• Common options:
  • Hydrochlorothiazide
  • Chlorthalidone

3. NSAIDs

• Supplementary treatment for Nephrogenic DI
• Examples: Indomethacin

Administration Guidelines

Desmopressin Tips

1. Take at consistent times
2. Monitor fluid intake
3. Watch for signs of water intoxication

Storage Requirements

• Keep nasal sprays at room temperature
• Protect tablets from moisture
• Check expiration dates regularly

Side Effects to Monitor

Common Side Effects

• Headache
• Nausea
• Nasal irritation (spray form)

Warning Signs

• Severe headache
• Confusion
• Seizures
• Unusual weight gain

When to Contact Your Doctor

• Medication seems less effective
• Experiencing concerning side effects
• Changes in urination patterns
• Before starting new medications

Regular Monitoring

• Blood sodium levels
• Urine output
• Body weight
• Blood pressure