Understanding Bile Duct Cancer (Cholangiocarcinoma)

A Comprehensive Guide for Patients and Caregivers

Oncology

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Last updated: Mar 24, 2025

What Is Bile Duct Cancer?

Bile duct cancer, also known as cholangiocarcinoma, is a rare cancer that develops in the bile ducts. These ducts are thin tubes that carry bile from your liver to your gallbladder and small intestine.

Types of Bile Duct Cancer

  • Intrahepatic - occurs inside the liver
  • Perihilar - develops where ducts exit the liver
  • Distal - affects ducts near the small intestine

Risk Factors

  • Chronic liver diseases
  • Primary sclerosing cholangitis
  • Age (typically affects people over 65)
  • Liver fluke infections
  • Bile duct stones
  • Inflammatory bowel disease

Common Symptoms

  • Jaundice (yellowing of skin and eyes)
  • Dark urine
  • Light-colored stools
  • Abdominal pain
  • Unexplained weight loss
  • Loss of appetite
  • Fever
  • Itchy skin

Diagnosis

Initial Tests

  • Blood tests
  • Liver function tests
  • Tumor markers

Imaging Studies

  • CT scan
  • MRI
  • MRCP (Magnetic Resonance Cholangiopancreatography)
  • ERCP (Endoscopic Retrograde Cholangiopancreatography)

Treatment Options

Surgery

  • Complete removal of tumor
  • Partial liver resection
  • Liver transplantation in select cases

Other Treatments

  • Chemotherapy
  • Radiation therapy
  • Targeted therapy
  • Immunotherapy

Palliative Care

  • Stent placement
  • Pain management
  • Nutritional support

Prognosis and Outlook

Prognosis varies depending on:

  • Cancer stage at diagnosis
  • Location of tumor
  • Overall health status
  • Treatment response

Living with Bile Duct Cancer

  • Regular medical follow-up
  • Dietary modifications
  • Lifestyle adjustments
  • Support groups
  • Mental health care

Prevention

  • Regular check-ups
  • Liver health maintenance
  • Avoiding risk factors
  • Healthy lifestyle choices

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