Total Protein Test

Understanding Your Blood Protein Levels

Internal Medicine

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Last updated: Mar 24, 2025

What is a Total Protein Test?

A total protein test measures the total amount of two classes of proteins found in the fluid portion of your blood:

  • Albumin: Makes up about 60% of total protein
  • Globulins: Include various proteins like antibodies

Purpose of the Test

Your healthcare provider may order this test to:

  • Screen for nutritional problems
  • Check liver and kidney function
  • Diagnose certain medical conditions
  • Monitor treatment response

Normal Range

  • Adults: 6.0 to 8.3 g/dL (60 to 83 g/L)
  • Values may vary slightly between laboratories

When Is It Ordered?

The test may be ordered when you have:

  • Unexplained weight loss
  • Fatigue
  • Edema (swelling)
  • Changes in urination

Preparation

  • Usually no special preparation needed
  • Fasting may be required in some cases
  • Inform your doctor about medications

Abnormal Results

High Protein Levels May Indicate:

  • Dehydration
  • Chronic inflammation
  • Multiple myeloma
  • Autoimmune conditions

Low Protein Levels May Indicate:

  • Malnutrition
  • Liver disease
  • Kidney disease
  • Malabsorption disorders

Follow-Up

Your healthcare provider may order additional tests if results are abnormal, such as:

  • Comprehensive metabolic panel
  • Serum protein electrophoresis
  • Immunoglobulin tests

Risks

Minimal risks associated with standard blood draw:

  • Slight pain
  • Minor bruising
  • Rare infection risk

When to Contact Your Doctor

Contact your healthcare provider if you experience:

  • Unexpected symptoms
  • Questions about results
  • Concerns about follow-up care

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