Gilbert's Syndrome: A Guide for Patients

Overview

Gilbert's syndrome is a common, inherited condition that affects how your liver processes bilirubin, a yellow substance produced when red blood cells break down.

Key Facts

• Affects approximately 3-7% of the population
• Usually discovered incidentally during routine blood tests
• Generally harmless and requires no treatment
• More common in males than females

Symptoms

Most people with Gilbert's syndrome experience:

• Mild jaundice (yellowing of skin/eyes)
• Fatigue
• Weakness
• Mild abdominal discomfort

Trigger Factors

Symptoms may worsen during:

• Stress
• Illness
• Fasting
• Dehydration
• Physical exertion
• Lack of sleep

Diagnosis

• Blood tests showing elevated unconjugated bilirubin
• Normal liver function tests
• Genetic testing (rarely needed)

Management

Lifestyle Modifications

• Maintain regular eating patterns
• Stay well-hydrated
• Get adequate sleep
• Manage stress levels
• Avoid excessive alcohol

Prognosis

• Excellent long-term outlook
• No impact on life expectancy
• No serious complications

When to Seek Medical Advice

Consult your healthcare provider if:

• Jaundice becomes severe
• You experience persistent abdominal pain
• Symptoms significantly affect daily life

Important Notes

• Safe during pregnancy
• No dietary restrictions required
• May affect certain medication metabolisms

Living with Gilbert's Syndrome

Most people lead completely normal lives with no limitations on activities or lifestyle.